Pub. Date : 2004 May 6
PMID : 14990993
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At equimolar concentrations, Tam and tamoxifen ethyl bromide (QTam), a membrane impermeant analog of Tam, rapidly induced apoptosis in HMEC-E6 cells associated with an even more rapid decrease in phosphorylation of AKT at serine-473. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Here, we show that plasma membrane-associated E2-binding sites initiate the rapid apoptotic effects of Tam in HMEC-E6 cells through modulation of AKT activity. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | At equimolar concentrations, Tam and tamoxifen ethyl bromide (QTam), a membrane impermeant analog of Tam, rapidly induced apoptosis in HMEC-E6 cells associated with an even more rapid decrease in phosphorylation of AKT at serine-473. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | The effects of both Tam and QTam were blocked by expression of constitutively active AKT (myristoylated AKT or AKT-Thr308Asp/Ser473Asp). | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | The effects of both Tam and QTam were blocked by expression of constitutively active AKT (myristoylated AKT or AKT-Thr308Asp/Ser473Asp). | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | The effects of both Tam and QTam were blocked by expression of constitutively active AKT (myristoylated AKT or AKT-Thr308Asp/Ser473Asp). | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 8 | These data indicate that Tam and QTam induce apoptosis in HMEC-E6 cells through a plasma membrane-activated AKT-signaling pathway that results in (1) decreased AKT phosphorylation at Ser-473, (2) mitochondrial membrane depolarization, and (3) activated caspase-9 and -3. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 9 | These data indicate that Tam and QTam induce apoptosis in HMEC-E6 cells through a plasma membrane-activated AKT-signaling pathway that results in (1) decreased AKT phosphorylation at Ser-473, (2) mitochondrial membrane depolarization, and (3) activated caspase-9 and -3. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |