Pub. Date : 2004 Jul
PMID : 14982968
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of the neutralizing activity of digoxin-specific Fab toward ouabain-like steroids. | Digoxin | FA complementation group B | Homo sapiens |
| 2 | Digoxin-specific Fab (Digibind) is a mixture of antidigoxin Fab fragments prepared from sheep sera and is used as a treatment for digoxin poisoning. | Digoxin | FA complementation group B | Homo sapiens |
| 3 | Digoxin-specific Fab (Digibind) is a mixture of antidigoxin Fab fragments prepared from sheep sera and is used as a treatment for digoxin poisoning. | Digoxin | FA complementation group B | Homo sapiens |
| 4 | Digoxin-specific Fab (Digibind) is a mixture of antidigoxin Fab fragments prepared from sheep sera and is used as a treatment for digoxin poisoning. | Digoxin | FA complementation group B | Homo sapiens |
| 5 | Digoxin-specific Fab has been shown to neutralize an endogenous Na+/K+ ATPase inhibitor (endogenous digoxin-like Na+/K+ ATPase regulatory factor; EDLF) in rats and humans and to lower blood pressure. | Digoxin | FA complementation group B | Homo sapiens |
| 6 | In this study, some structural characteristics of EDLF were inferred from the ability of digoxin-specific Fab to neutralize the Na+/K+ ATPase inhibitory activity of several known cardenolides and bufodienolides. | Digoxin | FA complementation group B | Homo sapiens |
| 7 | Digoxin-specific Fab had the ability to interact to some extent with all of the cardenolides and bufodienolides tested. | Digoxin | FA complementation group B | Homo sapiens |
| 8 | However, digoxin-specific Fab was more than 20-fold more potent in neutralizing ouabain and bufalin than marinobufagenin. | Digoxin | FA complementation group B | Homo sapiens |
| 9 | The antihypertensive effect of digoxin-specific Fab seen in preeclampsia and animal models of hypertension may therefore be due to a molecule identical to or structurally similar to ouabain or bufalin. | Digoxin | FA complementation group B | Homo sapiens |