Title : Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells.

Pub. Date : 2000 Jul

PMID : 14973392






1 Functional Relationships(s)
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Protein Name
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1 AhR-mediated inhibition of E2-induced cathepsin D, pS2, c-fos, and heat shock protein 27 gene expression involves direct interaction of the AhR complex with inhibitory pentanucleotide (GCGTG) dioxin responsive elements (iDREs) resulting in disruption of interactions between proteins binding DNA elements required for ER action and the basal transcription machinery. pentanucleotide Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens