Title : 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.

Pub. Date : 2004 Feb 15

PMID : 14973075






4 Functional Relationships(s)
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Protein Name
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1 Celecoxib and DMC block Akt activation in PC-3 cells through the inhibition of phosphoinositide-dependent kinase-1 (PDK-1) with IC(50) of 48 and 38 micro M, respectively. methyl carbonate AKT serine/threonine kinase 1 Homo sapiens
2 However, a correlation exists between the in vitro potency of DMC and its ability at 200 mg/kg to inhibit xenograft tumor growth through the inhibition of Akt activation. methyl carbonate AKT serine/threonine kinase 1 Homo sapiens
3 Analysis of the tumor samples indicates that a differential reduction in the phospho-Akt/Akt ratio was noted in celecoxib- and DMC-treated groups vis-a-vis the control group. methyl carbonate AKT serine/threonine kinase 1 Homo sapiens
4 Analysis of the tumor samples indicates that a differential reduction in the phospho-Akt/Akt ratio was noted in celecoxib- and DMC-treated groups vis-a-vis the control group. methyl carbonate AKT serine/threonine kinase 1 Homo sapiens