Title : CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.

Pub. Date : 2004 Feb 1

PMID : 14871834






2 Functional Relationships(s)
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1 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. Cyclic AMP CD47 molecule Homo sapiens
2 Thus, CD47-mediated killing of breast cancer cells occurs by a novel pathway involving regulation of cAMP levels by heterotrimeric Gi with subsequent effects mediated by PKA. Cyclic AMP CD47 molecule Homo sapiens