Pub. Date : 2004 Jan
PMID : 14758567
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol stimulates vascular endothelial growth factor and interleukin-6 in human lactotroph and lactosomatotroph pituitary adenomas. | Estradiol | vascular endothelial growth factor A | Homo sapiens |
| 2 | We have studied whether estradiol stimulates the production of the angiogenic vascular endothelial growth factor and the potential tumor progression factor interleukin-6 in 5 lactotroph (LA) and 5 lactosomatotroph (LSA) human pituitary adenoma cell cultures. | Estradiol | vascular endothelial growth factor A | Homo sapiens |
| 3 | Estradiol (100 nM) significantly enhanced VEGF release in all LA and LSA cell cultures (47 to 168 % above basal). | Estradiol | vascular endothelial growth factor A | Homo sapiens |
| 4 | In cell cultures obtained from tumors from which sufficient cells could be isolated, a dose-dependent effect of estradiol (1 to 100 nM) on VEGF and IL-6 production was observed. | Estradiol | vascular endothelial growth factor A | Homo sapiens |