Pub. Date : 2004 Feb 15
PMID : 14757171
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genistein also enhanced the expression of the cell cycle inhibitor, p21waf1/cip1, which interacts with Cdc2. | Genistein | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | Caffeine, an ATM kinase inhibitor, inhibited these effects of genistein on Chk2, p53, and p21waf1/cip1. | Genistein | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | These findings suggest that the effect of genistein on G2/M arrest in HepG2 cells is partly due to ATM-dependent Chk2 activation, an increase in Cdc2 phosphorylation/inactivation as a result of induction of Wee1 expression, and a decrease in Cdc2 activity as a result of induction of p21waf1/cip1 expression. | Genistein | cyclin dependent kinase inhibitor 1A | Homo sapiens |