Title : p53 protects from replication-associated DNA double-strand breaks in mammalian cells.

Pub. Date : 2004 Mar 25

PMID : 14743204






2 Functional Relationships(s)
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1 Here, we report that p53-/- mouse embryonic fibroblasts (MEFs) exhibit higher levels of the RAD51 protein and increased level of spontaneous RAD51 foci Agents that stall replication forks, for example, hydroxyurea (HU), potently induce HR repair and RAD51 foci. Hydroxyurea RAD51 recombinase Mus musculus
2 Here, we report that p53-/- mouse embryonic fibroblasts (MEFs) exhibit higher levels of the RAD51 protein and increased level of spontaneous RAD51 foci Agents that stall replication forks, for example, hydroxyurea (HU), potently induce HR repair and RAD51 foci. Hydroxyurea RAD51 recombinase Mus musculus