Pub. Date : 2004 Jun
PMID : 14742312
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. | Plutonium | cyclin dependent kinase inhibitor 2A | Homo sapiens |
| 2 | Stratification of plutonium exposure into tertiles also revealed a striking dose response for methylation of the p16 gene (P = 0.008). | Plutonium | cyclin dependent kinase inhibitor 2A | Homo sapiens |
| 3 | Here we demonstrate that exposure to plutonium may elevate the risk for adenocarcinoma through specifically targeting the p16 gene for inactivation by promoter methylation. | Plutonium | cyclin dependent kinase inhibitor 2A | Homo sapiens |