Pub. Date : 2004 Feb
PMID : 14741428
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thirty minutes of exposure to the selective P2X7 agonist 2"-3"-O-(4-benzoylbenzoyl)adenosine 5"-triphosphate (BzATP) resulted in the secretion of IL-1beta after either Abeta(1-42) or LPS stimulation of human macrophages that was dependent on the concentration of the stimulus used to pre-activate the cells. | BzATP | interleukin 1 beta | Homo sapiens |
| 2 | Further tests on human microglia treated with BzATP (300 microM) resulted in a 1.5- and 3.5-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 10 microM Abeta(1-42) and a 1.6- and 3.9-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 1 microg/ml LPS. | BzATP | interleukin 1 beta | Homo sapiens |
| 3 | Further tests on human microglia treated with BzATP (300 microM) resulted in a 1.5- and 3.5-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 10 microM Abeta(1-42) and a 1.6- and 3.9-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 1 microg/ml LPS. | BzATP | interleukin 1 beta | Homo sapiens |
| 4 | BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP). | BzATP | interleukin 1 beta | Homo sapiens |