Pub. Date : 1992 Dec 15
PMID : 1471975
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The microfilament-disrupting agent cytochalasin D (CD) increased (by 10-22-fold) the synthesis de novo and extracellular matrix deposition of plasminogen-activator inhibitor type-1 [p52(PAI-1)] in normal rat kidney (NRK) cells. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 2 | The microfilament-disrupting agent cytochalasin D (CD) increased (by 10-22-fold) the synthesis de novo and extracellular matrix deposition of plasminogen-activator inhibitor type-1 [p52(PAI-1)] in normal rat kidney (NRK) cells. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 3 | CD-associated increases in p52(PAI-1) mRNA abundance and protein biosynthesis were maximal between 6 and 8 h of continuous CD exposure, declined by 50% thereafter, but remained elevated (by at least 6-21-fold respectively over control values) for 24 h. Changes in p52(PAI-1) mRNA abundance at this 24 h point reflected an approx. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 4 | CD-associated increases in p52(PAI-1) mRNA abundance and protein biosynthesis were maximal between 6 and 8 h of continuous CD exposure, declined by 50% thereafter, but remained elevated (by at least 6-21-fold respectively over control values) for 24 h. Changes in p52(PAI-1) mRNA abundance at this 24 h point reflected an approx. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 5 | CD-associated increases in p52(PAI-1) mRNA abundance and protein biosynthesis were maximal between 6 and 8 h of continuous CD exposure, declined by 50% thereafter, but remained elevated (by at least 6-21-fold respectively over control values) for 24 h. Changes in p52(PAI-1) mRNA abundance at this 24 h point reflected an approx. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 6 | 284, 433-439], that CD-mediated increases in p52(PAI-1) expression are at least partly due to transcription-level events. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 7 | Induction of p52(PAI-1) synthesis and matrix deposition in CD-stimulated quiescent NRK cells was as efficient under growth-factor-deficient conditions as when CD was added simultaneously with serum. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 8 | Induction of p52(PAI-1) synthesis and matrix deposition in CD-stimulated quiescent NRK cells was as efficient under growth-factor-deficient conditions as when CD was added simultaneously with serum. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 9 | CD alone is thus a complete inducer of p52(PAI-1) expression in NRK cells, an observation that supports the contention that cell shape is an important regulatory element in p52(PAI-1)-gene control. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |
| 10 | CD alone is thus a complete inducer of p52(PAI-1) expression in NRK cells, an observation that supports the contention that cell shape is an important regulatory element in p52(PAI-1)-gene control. | Cytochalasin D | similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52) | Rattus norvegicus |