Title : Neuregulin signaling on glucose transport in muscle cells.

Pub. Date : 2004 Mar 26

PMID : 14711829






3 Functional Relationships(s)
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1 In contrast, transduction of L6E9 myotubes with adenoviruses encoding a dominant negative kinase-inactive PKCzeta abolished both HRG- and insulin-stimulated glucose uptake. Glucose protein kinase C zeta Homo sapiens
2 In all, HRG stimulated glucose transport in muscle cells by activation of a pathway that requires PI3K, PDK1, and PKCzeta, but not PKB, and that shows cross-talk with the MAPK pathway. Glucose protein kinase C zeta Homo sapiens
3 The PI3K, PDK1, and PKCzeta pathway can be considered as an alternative mechanism, independent of insulin, to induce glucose uptake. Glucose protein kinase C zeta Homo sapiens