Pub. Date : 2004 Jan
PMID : 14704332
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lecithin:retinol acyltransferase (LRAT), a microsomal enzyme present in liver and several other retinol-metabolizing tissues, esterifies retinol that is associated with a cellular retinol-binding protein, CRBP or CRBP-II. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 2 | Lecithin:retinol acyltransferase (LRAT), a microsomal enzyme present in liver and several other retinol-metabolizing tissues, esterifies retinol that is associated with a cellular retinol-binding protein, CRBP or CRBP-II. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 3 | Lecithin:retinol acyltransferase (LRAT), a microsomal enzyme present in liver and several other retinol-metabolizing tissues, esterifies retinol that is associated with a cellular retinol-binding protein, CRBP or CRBP-II. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 4 | Lecithin:retinol acyltransferase (LRAT), a microsomal enzyme present in liver and several other retinol-metabolizing tissues, esterifies retinol that is associated with a cellular retinol-binding protein, CRBP or CRBP-II. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 5 | Lecithin:retinol acyltransferase (LRAT), a microsomal enzyme present in liver and several other retinol-metabolizing tissues, esterifies retinol that is associated with a cellular retinol-binding protein, CRBP or CRBP-II. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 6 | In vitamin A-deficient liver, both LRAT mRNA and activity are significantly down-regulated as well as rapidly induced after the administration of vitamin A or its principal hormonal metabolite, retinoic acid (RA). | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 7 | In long-term feeding studies and the metabolic steady state, liver LRAT is expressed dose-dependently across a wide range of dietary vitamin A. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 8 | Based on these results, we propose that LRAT and CYP26 serve as two molecular mechanisms, coordinately regulated by all-trans-RA, to control the availability of retinol and RA, respectively. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 9 | The LRAT reaction, besides providing a readily retrievable storage form of vitamin A, may regulate the availability of retinol to other pathways, while the CYP26 reaction may serve to prevent a detrimental "overshoot" of RA concentration. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |
| 10 | The LRAT reaction, besides providing a readily retrievable storage form of vitamin A, may regulate the availability of retinol to other pathways, while the CYP26 reaction may serve to prevent a detrimental "overshoot" of RA concentration. | Vitamin A | lecithin retinol acyltransferase | Homo sapiens |