Title : Tyrosine kinase, p56lck-induced cell motility, and urokinase-type plasminogen activator secretion involve activation of epidermal growth factor receptor/extracellular signal regulated kinase pathways.

Pub. Date : 2004 Mar 12

PMID : 14699120






1 Functional Relationships(s)
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1 To our knowledge, this is the first report that p56(lck) in presence of H/R regulates MEK-1-dependent ERK1/2 phosphorylation and uPA secretion through tyrosine phosphorylation of EGF receptor, and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells. Tyrosine mitogen-activated protein kinase kinase 1 Homo sapiens