Title : Estrogen suppresses IL-1beta-mediated induction of COX-2 pathway in rat cerebral blood vessels.

Pub. Date : 2004 May

PMID : 14684367






2 Functional Relationships(s)
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1 IL-1beta increased PGE2 but not PGI2 production and decreased vascular tone as measured in isolated cerebral arteries; the latter effect was partially reversed by treatment with the selective COX-2 inhibitor NS-398 (10 micromol/l). Dinoprostone interleukin 1 beta Rattus norvegicus
2 Combined treatment with 17beta-estradiol and medroxyprogesterone acetate also prevented increases in PGE2 production after IL-1beta treatment, but treatment with 17alpha-estradiol had no effect. Dinoprostone interleukin 1 beta Rattus norvegicus