Title : Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.

Pub. Date : 2004 Jan

PMID : 14665560






1 Functional Relationships(s)
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1 RESULTS: The amide local anaesthetics bupivacaine, levobupivacaine and ropivacaine inhibited HERG channels at toxicologically relevant concentrations, with IC(50) values of 20 (SEM 2) micro M (n=29), 10 (1) micro M (n=40) and 20 (2) micro M (n=49), respectively. Bupivacaine potassium voltage-gated channel subfamily H member 2 Homo sapiens