Pub. Date : 2003 Dec
PMID : 14662165
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To determine the change in expression of the Wilms tumor suppressor gene product, WT1, by progesterone alone in endometrial stromal cell culture and to study its relationship with prolactin, a marker of decidualization. | Progesterone | WT1 transcription factor | Homo sapiens |
| 2 | RESULTS: Reverse transcription and real-time PCR revealed a significant increase in WT1 mRNA with increasing progesterone concentrations when decidualization was occurring (n = 6, P =.002). | Progesterone | WT1 transcription factor | Homo sapiens |
| 3 | CONCLUSION: The changing expression of WT1 isoforms in endometrial stromal cells caused by progesterone may be important for differentiation into the decidualized phenotype. | Progesterone | WT1 transcription factor | Homo sapiens |