Title : Cyclopiazonic acid discharges intracellular Ca2+ stores and stimulates Ca2+ influx in cultured human gingival fibroblasts.

Pub. Date : 2003 Sep

PMID : 14650578






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The effect of cyclopiazonic acid (CPA) on changes in the intracellular free Ca2+ concentration ([Ca2+]i) evoked by bradykinin (BK), histamine (HIST) and thapsigargin (TG) was investigated in human gingival fibroblasts. cyclopiazonic acid kininogen 1 Homo sapiens
2 The effect of cyclopiazonic acid (CPA) on changes in the intracellular free Ca2+ concentration ([Ca2+]i) evoked by bradykinin (BK), histamine (HIST) and thapsigargin (TG) was investigated in human gingival fibroblasts. cyclopiazonic acid kininogen 1 Homo sapiens
3 Pretreatment with CPA (< 5 microM) enhanced the [Ca2+]i responses evoked by 5 nM BK and 1 mM HIST. cyclopiazonic acid kininogen 1 Homo sapiens
4 Moreover, CPA accelerated the Ca2+ influx caused by 5 nM BK and 1mM HIST, but did not alter that caused by 1 microM TG. cyclopiazonic acid kininogen 1 Homo sapiens