Title : Statins induce suppressor of cytokine signaling-3 in macrophages.

Pub. Date : 2003 Dec 4

PMID : 14644448






1 Functional Relationships(s)
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1 This effect is specific for SOCS-3 and could be blocked by mevalonate, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, while it was not affected by inhibitors of protein kinase C and A, mitogen-activated protein/extracellular signal-regulated kinase kinase, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, Src, Raf and Rho kinase. farnesyl pyrophosphate suppressor of cytokine signaling 3 Homo sapiens