Title : Effects of statins on adhesion molecule expression in endothelial cells.

Pub. Date : 2003 Nov

PMID : 14629460






2 Functional Relationships(s)
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1 RESULTS: Pretreatment with simvastatin, fluvastatin or pravastatin potentiated the TNF-alpha and LPS-induced expression of E-selectin and VCAM-1, and mevalonate reversed the potentiating effect of these statins. Simvastatin tumor necrosis factor Homo sapiens
2 Furthermore, GGTI-286, but not FTI-277, mimicked the effect of simvastatin by increasing the TNF-alpha-mediated overexpression of E-selectin. Simvastatin tumor necrosis factor Homo sapiens