Pub. Date : 2003 Oct
PMID : 14626664
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Exposure of fibroblasts to 1O2 elicited a strong and sustained phosphorylation of Akt, which occurred concurrently with phosphorylation of p38 kinase, a proapoptotic signal. | CHEBI:63768 | thymoma viral proto-oncogene 1 | Mus musculus |
2 | Significantly, cell death induced by 1O2 was enhanced by inhibition of PI3-K, suggesting that activation of Akt by 1O2 may contribute to fibroblast survival under this form of oxidative stress. | CHEBI:63768 | thymoma viral proto-oncogene 1 | Mus musculus |
3 | Significantly, cell death induced by 1O2 was enhanced by inhibition of PI3-K, suggesting that activation of Akt by 1O2 may contribute to fibroblast survival under this form of oxidative stress. | CHEBI:63768 | thymoma viral proto-oncogene 1 | Mus musculus |
4 | Activation of neither focal adhesion kinase (FAK) nor Ras protein, both of which mediate responses to reactive oxygen species, appeared to be pathways for the 1O2-induced activation of the PI3-K-Akt survival pathway. | CHEBI:63768 | thymoma viral proto-oncogene 1 | Mus musculus |
5 | Thus, activation of Akt by 1O2 is mediated by PI3-K and contributes to a survival response that counteracts cell death after 1O2-induced injury. | CHEBI:63768 | thymoma viral proto-oncogene 1 | Mus musculus |
6 | However, unlike the response to other oxidants, activation of the PI3-K-Akt by 1O2 does not involve activation of growth factor receptors, FAK or Ras protein. | CHEBI:63768 | thymoma viral proto-oncogene 1 | Mus musculus |