Title : Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine.

Pub. Date : 2003 Nov

PMID : 14622152






1 Functional Relationships(s)
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1 Using a previously validated model of in vitro superfusion, we show that the nAChR agonists nicotine (EC50 557 micro m), epibatidine (EC50 317 pm) and cytisine (EC50 4.83 nm) potentiated capsaicin-evoked iCGRP release in a concentration-dependent manner by 123, 70 and 76%, respectively. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus