Title : [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells].

Pub. Date : 2003 Oct

PMID : 14619570






10 Functional Relationships(s)
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1 OBJECTIVE: To explore the effects of arsenic trioxide (As2O3) on tissue factor (TF), plasminogen activator inhibitor-1(PAI-I) and PAI-2 expression in NB4, HL-60 and THP-1 cells. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
2 OBJECTIVE: To explore the effects of arsenic trioxide (As2O3) on tissue factor (TF), plasminogen activator inhibitor-1(PAI-I) and PAI-2 expression in NB4, HL-60 and THP-1 cells. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
3 OBJECTIVE: To explore the effects of arsenic trioxide (As2O3) on tissue factor (TF), plasminogen activator inhibitor-1(PAI-I) and PAI-2 expression in NB4, HL-60 and THP-1 cells. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
4 The TF antigen levels were down-regulated during the As2O3-induced apoptosis of NB4 cells (P < 0.01), and the down-regulation effect of TF antigen levels was in the As2O3-concentration dependent fashion. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
5 The TF antigen levels were down-regulated during the As2O3-induced apoptosis of NB4 cells (P < 0.01), and the down-regulation effect of TF antigen levels was in the As2O3-concentration dependent fashion. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
6 The TF antigen levels were up-regulated and the PAI-2 antigen levels were down-regulated during the As2O3-induced apoptosis of HL-60 cells (P < 0.01 and P < 0.05, TF and PAI-2 respectively). Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
7 The TF antigen levels were up-regulated and the PAI-2 antigen levels were down-regulated during the As2O3-induced apoptosis of HL-60 cells (P < 0.01 and P < 0.05, TF and PAI-2 respectively). Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
8 The TF and PAI-2 antigen levels in THP-1 cells were up-regulated after the exposure to 8 mumol/L As2O3 for 24 h (P < 0.05 and P < 0.01, TF and PAI-2 respectively). Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
9 The TF and PAI-2 antigen levels in THP-1 cells were up-regulated after the exposure to 8 mumol/L As2O3 for 24 h (P < 0.05 and P < 0.01, TF and PAI-2 respectively). Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
10 CONCLUSION: The effects of As2O3 on TF, PAI-1 and PAI-2 antigen levels in NB4, HL-60 and THP-1 cells are distinct. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens