Title : Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes.

Pub. Date : 2003 Dec

PMID : 14618335






2 Functional Relationships(s)
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1 The small GTPase Rab5 as well as the PI(3)P-binding proteins EEA1, SARA and CISK were found to be abundant within PI(3)P-containing endosomal microdomains. 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'D-myo-inositol-3'-phosphate) RAB5A, member RAS oncogene family Homo sapiens
2 While PI(3)P-containing microdomains could be readily distinguished on enlarged endosomes in cells transfected with a constitutively active Rab5 mutant, such domains could also be detected in endosomes of non-transfected cells. 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'D-myo-inositol-3'-phosphate) RAB5A, member RAS oncogene family Homo sapiens