Title : Participation of endogenous dehydroepiandrosterone and its sulfate in the pathology of collagen-induced arthritis in mice.

Pub. Date : 2003 Nov

PMID : 14600408






5 Functional Relationships(s)
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1 We have investigated the serum levels of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) in type II collagen (CII)-induced arthritis (CIA) DBA/1J mice, an experimental model of human rheumatoid arthritis (RA). Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus
2 However, in CIA mice, DHEA levels on day 28 and 48 were not decreased from those on day 6. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus
3 The time point for the retention of DHEA in CIA mice, day 28 and day 48, coincided with the disease onset of CIA. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus
4 The time point for the retention of DHEA in CIA mice, day 28 and day 48, coincided with the disease onset of CIA. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus
5 In conclusion, endogenous DHEA may be produced as a result of physiological response for the protection against CIA. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus