Title : Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

Pub. Date : 2003 Nov 15

PMID : 14599561






2 Functional Relationships(s)
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1 Previous studies have shown that DCA decreases MAAI activity in rat liver in a time- and dose-dependent manner and may target the protein for degradation in vivo. Dichloroacetic Acid glutathione S-transferase zeta 1 Rattus norvegicus
2 We now report that the MAAI protein is depleted in a time- and dose-dependent manner in the livers of Sprague-Dawley rats exposed to DCA. Dichloroacetic Acid glutathione S-transferase zeta 1 Rattus norvegicus