Title : Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells.

Pub. Date : 2003 Nov 15

PMID : 14592454






1 Functional Relationships(s)
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1 Mechanistically, inhibition of telomerase by endogenous ceramide in response to ATRA treatment involves, at least in part, down-regulation of the expression of telomerase reverse transcriptase (hTERT) mRNA, as determined by semi-quantitative RT-PCR, in these cells. Ceramides telomerase reverse transcriptase Homo sapiens