Title : 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.

Pub. Date : 2003 Nov 6

PMID : 14584948






2 Functional Relationships(s)
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1 Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of P2Y(1) receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al. Ribose purinergic receptor P2Y1 Homo sapiens
2 Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of P2Y(1) receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al. Ribose purinergic receptor P2Y1 Homo sapiens