Pub. Date : 2003 Nov 3
PMID : 14583781
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Using an isogenic cell system, we demonstrate that c-Myc overexpression in colon carcinoma LoVo cells resulted in sensitisation to camptothecin-induced apoptosis, thus identifying c-Myc as a potential marker predicting response of colorectal tumour cells to camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | Using an isogenic cell system, we demonstrate that c-Myc overexpression in colon carcinoma LoVo cells resulted in sensitisation to camptothecin-induced apoptosis, thus identifying c-Myc as a potential marker predicting response of colorectal tumour cells to camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Using an isogenic cell system, we demonstrate that c-Myc overexpression in colon carcinoma LoVo cells resulted in sensitisation to camptothecin-induced apoptosis, thus identifying c-Myc as a potential marker predicting response of colorectal tumour cells to camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | Using an isogenic cell system, we demonstrate that c-Myc overexpression in colon carcinoma LoVo cells resulted in sensitisation to camptothecin-induced apoptosis, thus identifying c-Myc as a potential marker predicting response of colorectal tumour cells to camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | Both camptothecin exposure and c-Myc overexpression in LoVo cells resulted in elevation of p53 protein levels, suggesting a role of p53 in the c-Myc-imposed sensitisation to the apoptotic effects of camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 7 | Both camptothecin exposure and c-Myc overexpression in LoVo cells resulted in elevation of p53 protein levels, suggesting a role of p53 in the c-Myc-imposed sensitisation to the apoptotic effects of camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 8 | Both camptothecin exposure and c-Myc overexpression in LoVo cells resulted in elevation of p53 protein levels, suggesting a role of p53 in the c-Myc-imposed sensitisation to the apoptotic effects of camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 9 | Importantly, although camptothecin treatment markedly increased p21(Waf1/Cip1) levels in parental LoVo cells, this effect was abrogated in c-Myc-overexpressing derivatives. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 10 | Finally, cDNA microarray analysis was used to identify genes that are modulated in expression by c-Myc upregulation that could serve as additional markers predicting response to camptothecin. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |