Pub. Date : 2004 Jan 2
PMID : 14576150
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines. | Nitric Oxide | tumor protein p53 | Homo sapiens |
| 2 | Strikingly, we observed that the depletion of nitric oxide inhibits cisplatin-induced wild type p53 accumulation and p21(Waf1/Cip1/Sdi1) expression in melanoma cells. | Nitric Oxide | tumor protein p53 | Homo sapiens |
| 3 | When cisplatin-induced p53 binding to the p21(Waf1/Cip1/Sdi1) promoter was examined, it was found that nitric oxide depletion significantly reduced the presence of p53-DNA complexes after cisplatin treatment. | Nitric Oxide | tumor protein p53 | Homo sapiens |
| 4 | When cisplatin-induced p53 binding to the p21(Waf1/Cip1/Sdi1) promoter was examined, it was found that nitric oxide depletion significantly reduced the presence of p53-DNA complexes after cisplatin treatment. | Nitric Oxide | tumor protein p53 | Homo sapiens |
| 5 | Together, these data strongly suggest that endogenously produced nitric oxide is required for cisplatin-induced p53 activation and p21(Waf1/Cip1/Sdi1) expression, which can regulate melanoma sensitivity to cisplatin. | Nitric Oxide | tumor protein p53 | Homo sapiens |