Title : Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.

Pub. Date : 2003 Nov

PMID : 14573750






2 Functional Relationships(s)
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1 Expression of mGSTA3 in Hepa1c1c7 mouse hepatoma cells was found to be inducible by sulforaphane, an organic isothiocyanate that can transcriptionally activate genes through the antioxidant response element (ARE). sulforaphane glutathione S-transferase, alpha 3 Mus musculus
2 Sulforaphane also induced transcription of a luciferase reporter containing a 1.5 kb fragment of the mGSTA3 5"-upstream region. sulforaphane glutathione S-transferase, alpha 3 Mus musculus