Pub. Date : 2003 Oct
PMID : 14572452
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here, we describe a novel mechanism by which the HNK-1 carbohydrate carried by recognition molecules regulates perisomatic inhibition in the hippocampus. | Carbohydrates | beta-1,3-glucuronyltransferase 1 | Homo sapiens |
2 | This mechanism is supported by pharmacological analysis in hippocampal slices and data showing that the HNK-1 carbohydrate binds to GABA(B) receptors and inhibits GABA(B) receptor-activated K(+) currents in a heterologous expression system. | Carbohydrates | beta-1,3-glucuronyltransferase 1 | Homo sapiens |
3 | We suggest that the HNK-1 carbohydrate is involved in homeostatic regulation of GABA(A) receptor-mediated perisomatic inhibition by suppression of postsynaptic GABA(B) receptor activity. | Carbohydrates | beta-1,3-glucuronyltransferase 1 | Homo sapiens |