Title : Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses.

Pub. Date : 2003 Oct

PMID : 14572452






3 Functional Relationships(s)
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1 Here, we describe a novel mechanism by which the HNK-1 carbohydrate carried by recognition molecules regulates perisomatic inhibition in the hippocampus. Carbohydrates beta-1,3-glucuronyltransferase 1 Homo sapiens
2 This mechanism is supported by pharmacological analysis in hippocampal slices and data showing that the HNK-1 carbohydrate binds to GABA(B) receptors and inhibits GABA(B) receptor-activated K(+) currents in a heterologous expression system. Carbohydrates beta-1,3-glucuronyltransferase 1 Homo sapiens
3 We suggest that the HNK-1 carbohydrate is involved in homeostatic regulation of GABA(A) receptor-mediated perisomatic inhibition by suppression of postsynaptic GABA(B) receptor activity. Carbohydrates beta-1,3-glucuronyltransferase 1 Homo sapiens