Title : The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression.

Pub. Date : 2003 Nov

PMID : 14568251






11 Functional Relationships(s)
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1 The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. Iron solute carrier family 40 member 1 Homo sapiens
2 The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. Iron solute carrier family 40 member 1 Homo sapiens
3 The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. Iron solute carrier family 40 member 1 Homo sapiens
4 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron solute carrier family 40 member 1 Homo sapiens
5 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron solute carrier family 40 member 1 Homo sapiens
6 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron solute carrier family 40 member 1 Homo sapiens
7 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron solute carrier family 40 member 1 Homo sapiens
8 The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron. Iron solute carrier family 40 member 1 Homo sapiens
9 Then, in cells transfected with SLC40A1-DeltaIRE-Luc, we found that, in spite of iron regulatory protein activation, the response to iron manipulation was lost. Iron solute carrier family 40 member 1 Homo sapiens
10 CONCLUSIONS: We demonstrate that the iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system. Iron solute carrier family 40 member 1 Homo sapiens
11 CONCLUSIONS: We demonstrate that the iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system. Iron solute carrier family 40 member 1 Homo sapiens