Title : Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines.

Pub. Date : 2003 Oct 28

PMID : 14567703






1 Functional Relationships(s)
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1 Single-turnover excision of hypoxanthine and 1,N(6)-ethenoadenine follows bell-shaped pH-rate profiles, indicating that AAG-catalyzed excision of these neutral lesions requires the action of both a general acid and a general base. 1,N(6)-ethenoadenine N-methylpurine DNA glycosylase Homo sapiens