Pub. Date : 2003 Nov 1
PMID : 14563679
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that Ubp8, a component of the SAGA acetylation complex, is required for SAGA-mediated deubiquitylation of histone H2B in vitro. | ubp8 | H2B clustered histone 21 | Homo sapiens |
| 2 | Loss of Ubp8 in vivo increased both gene-associated and overall cellular levels of ubiquitylated H2B. | ubp8 | H2B clustered histone 21 | Homo sapiens |
| 3 | In addition, disruption of either ubiquitylation or Ubp8-mediated deubiquitylation of H2B resulted in altered levels of gene-associated H3 Lys 4 methylation and Lys 36 methylation, which have both been linked to transcription. | ubp8 | H2B clustered histone 21 | Homo sapiens |