Title : Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia.

Pub. Date : 2004 Feb 15

PMID : 14563637






1 Functional Relationships(s)
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1 In follicular lymphoma (FL), genomic polymorphisms corresponding to the expression of valine (V) or phenylalanine (F) at amino acid 158 of Fc gamma RIIIa alter the binding affinity of immunoglobulin G1 (IgG1) to the receptor and have been associated with varied responses to rituximab. Phenylalanine Fc gamma receptor IIIa Homo sapiens