Pub. Date : 2003 Oct 15
PMID : 14561820
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that the two types of lipid act by the same mechanism: oleoyl-CoA potently reduced the ATP sensitivity of cardiac (Kir6.2/SUR2A) and pancreatic (Kir6.2/SUR1) KATP channels in a way very similar to PIP2. | oleoyl-coenzyme A | potassium inwardly rectifying channel subfamily J member 11 | Homo sapiens |
| 2 | Here we show that the two types of lipid act by the same mechanism: oleoyl-CoA potently reduced the ATP sensitivity of cardiac (Kir6.2/SUR2A) and pancreatic (Kir6.2/SUR1) KATP channels in a way very similar to PIP2. | oleoyl-coenzyme A | potassium inwardly rectifying channel subfamily J member 11 | Homo sapiens |
| 3 | Mutations (R54Q, R176A) in the C- and N-terminus of Kir6.2 that greatly reduced the PIP2 modulation of ATP sensitivity likewise reduced the modulation by oleoyl-CoA, indicating that the two lipids interact with the same site. | oleoyl-coenzyme A | potassium inwardly rectifying channel subfamily J member 11 | Homo sapiens |