Title : Effects of thalidomide on parameters involved in angiogenesis: an in vitro study.

Pub. Date : 2003 Sep

PMID : 14558594






2 Functional Relationships(s)
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1 The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug. Thalidomide fibroblast growth factor 2 Homo sapiens
2 The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug. Thalidomide fibroblast growth factor 2 Homo sapiens