Pub. Date : 2003 Oct 15
PMID : 14556853
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also show that menadione, a superoxide anion generator and a highly reactive electrophile, operates both modes of Yap1 activation. | Superoxides | DNA-binding transcription factor YAP1 | Saccharomyces cerevisiae S288C |
| 2 | We propose that Yap1 has two distinct molecular redox centers, one triggered by ROS (hydroperoxides and the superoxide anion) and the other by chemicals with thiol reactivity (electrophiles and divalent heavy metals cations). | Superoxides | DNA-binding transcription factor YAP1 | Saccharomyces cerevisiae S288C |