Title : Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.

Pub. Date : 2003 Dec 19

PMID : 14532276






1 Functional Relationships(s)
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1 Abnormally high phosphorylation levels (hyperphosphorylation) at Ser-2843 in RyR1 and Ser-2809 in RyR2 and dissociation of FK506-binding proteins from the receptors have been implicated as one of the causes of altered calcium homeostasis observed during human heart failure. Tacrolimus ryanodine receptor 1 Homo sapiens