Title : Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells.

Pub. Date : 2003 Oct

PMID : 14529564






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In contrast, we demonstrated that in ER+ breast cancer cells the p21(WAF1/CIP1) gene was more sensitive to TSA regulation and was expressed at higher levels. trichostatin A cyclin dependent kinase inhibitor 1A Homo sapiens
2 In contrast, we demonstrated that in ER+ breast cancer cells the p21(WAF1/CIP1) gene was more sensitive to TSA regulation and was expressed at higher levels. trichostatin A cyclin dependent kinase inhibitor 1A Homo sapiens
3 The Sp1 transcription factor, which was shown to interact in vitro with both class I and class II HDACs, is sufficient to confer the differential sensitivity to TSA and participated in the control of p21(WAF1/CIP1) basal expression. trichostatin A cyclin dependent kinase inhibitor 1A Homo sapiens