Title : Inhibition of dog and human gastric lipases by enantiomeric phosphonate inhibitors: a structure-activity study.

Pub. Date : 2003 Oct 14

PMID : 14529268






1 Functional Relationships(s)
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1 Using the two previously determined structures and that of a new crystal structure obtained with the other (S(P))-phosphonate enantiomer [C(11)Y(4)(-)], we constructed models of phosphonate inhibitors fitting into the active site crevices of DGL and HGL. Organophosphonates lipase F, gastric type Homo sapiens