Pub. Date : 2003 Dec 19
PMID : 14527959
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that cIAP-2 mRNA levels were markedly increased in human colon cancer cells by treatment with the phorbol ester, phorbol-12-myristate-13-acetate (PMA), or bryostatin 1. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 2 | We found that cIAP-2 mRNA levels were markedly increased in human colon cancer cells by treatment with the phorbol ester, phorbol-12-myristate-13-acetate (PMA), or bryostatin 1. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 3 | Inhibitors of the Ca2+-independent, novel PKC isoforms, but not inhibitors of MAPK, PI3-kinase, or PKA, blocked PMA-stimulated cIAP-2 mRNA expression, suggesting a role of PKC in PMA-mediated cIAP-2 induction. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 4 | Inhibitors of the Ca2+-independent, novel PKC isoforms, but not inhibitors of MAPK, PI3-kinase, or PKA, blocked PMA-stimulated cIAP-2 mRNA expression, suggesting a role of PKC in PMA-mediated cIAP-2 induction. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 5 | Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 6 | Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 7 | Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |
| 8 | Treatment with the proteasome inhibitor, MG132 or inhibitors of NF-kappa B (e.g. PDTC and gliotoxin), decreased PMA-induced up-regulation of cIAP-2. | Tetradecanoylphorbol Acetate | baculoviral IAP repeat containing 3 | Homo sapiens |