Title : Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance.

Pub. Date : 2004 Jan

PMID : 14523051






2 Functional Relationships(s)
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1 Treatment of obob/APOC1(+/-) mice with rosiglitazone strongly improved whole-body insulin sensitivity as well as hepatic insulin sensitivity, despite a further increase of hepatic fatty acid (FA) uptake and a panlobular increase of hepatic TG accumulation. Rosiglitazone apolipoprotein C-I Mus musculus
2 We conclude that overexpression of APOC1 prevents rosiglitazone-induced peripheral FA uptake leading to severe hepatic steatosis. Rosiglitazone apolipoprotein C-I Mus musculus