Title : Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.

Pub. Date : 2003 Oct 17

PMID : 14521937






2 Functional Relationships(s)
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1 7-Ketocholesterol, an oxidized lipid in oxLDL particles, induced the production of fibronectin and the activation of SP-1, those which were suppressed by N-acetylcysteine. 7-ketocholesterol fibronectin 1 Rattus norvegicus
2 Furthermore, mithramycin A, an inhibitor of SP-1, also suppressed the oxLDL- and 7-ketocholesterol-stimulated production of fibronectin. 7-ketocholesterol fibronectin 1 Rattus norvegicus