Title : Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.

Pub. Date : 2003 Sep 15

PMID : 14507471






3 Functional Relationships(s)
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1 Agents such as lithium or glial cell-line derived neurotrophic factor (GDNF) have the ability to prevent aluminum-induced neuronal death by interfering with the mitochondrial and/or the endoplasmic reticulum-mediated apoptosis cascade. Aluminum glial cell line-derived neurotrophic factor Oryctolagus cuniculus
2 Agents such as lithium or glial cell-line derived neurotrophic factor (GDNF) have the ability to prevent aluminum-induced neuronal death by interfering with the mitochondrial and/or the endoplasmic reticulum-mediated apoptosis cascade. Aluminum glial cell line-derived neurotrophic factor Oryctolagus cuniculus
3 GDNF also protects against aluminum-induced apoptosis but by upregulation of Bcl-X(L), thereby preventing the binding of cytochrome c to Apaf-1. Aluminum glial cell line-derived neurotrophic factor Oryctolagus cuniculus