Title : Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.

Pub. Date : 2003 Sep 24

PMID : 14505498






2 Functional Relationships(s)
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1 BACKGROUND: Kynureninase is a key enzyme on the kynurenine pathway of tryptophan metabolism. Kynurenine kynureninase Homo sapiens
2 RESULTS: Two new kynurenine analogues, 3-hydroxydesaminokynurenine and 3-methoxydesaminokynurenine, were synthesised as inhibitors of kynureninase and tested on the tryptophan-induced bacterial enzyme from Pseudomonas fluorescens, the recombinant human enzyme and the rat hepatic enzyme. Kynurenine kynureninase Homo sapiens