Title : Molecular dynamics simulations of the ligand-induced chemical information transfer in the 5-HT(1A) receptor.

Pub. Date : 2003 Sep-Oct

PMID : 14502486






1 Functional Relationships(s)
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1 Despite the differences in the structural/dynamics behavior of the two agonists when docked into the 5-HT(1A) receptor, they both exert a destabilization of the intrahelical and interhelical interactions found in the empty and antagonist-bound receptor forms between the arginine of the E/DRY sequence and both D133(3.49) and E340(6.30). Arginine 5-hydroxytryptamine receptor 1A Homo sapiens