Title : The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model.

Pub. Date : 2003 Oct

PMID : 14501948






3 Functional Relationships(s)
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1 DHEA application was associated with a reduction of mortality of 100% in TNF-RI(-/-) mice after CLP to 50%. Dehydroepiandrosterone tumor necrosis factor receptor superfamily, member 1a Mus musculus
2 This result engages, that the effect of DHEA is TNF-RI independent. Dehydroepiandrosterone tumor necrosis factor receptor superfamily, member 1a Mus musculus
3 In contrast, DHEA seems to be TNF-RI independent. Dehydroepiandrosterone tumor necrosis factor receptor superfamily, member 1a Mus musculus