Title : Syntaxin 1A inhibits GABA flux, efflux, and exchange mediated by the rat brain GABA transporter GAT1.

Pub. Date : 2003 Oct

PMID : 14500747






4 Functional Relationships(s)
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1 Syntaxin 1A inhibits GABA flux, efflux, and exchange mediated by the rat brain GABA transporter GAT1. gamma-Aminobutyric Acid syntaxin 1A Rattus norvegicus
2 We have shown previously that syntaxin 1A exerts its effects on GAT1 by decreasing the net uptake of GABA and its associated ions through interactions with aspartic acid residues in the N-terminal tail of GAT1. gamma-Aminobutyric Acid syntaxin 1A Rattus norvegicus
3 The syntaxin 1A-mediated reduction in GABA flux and efflux was mimicked by mutations in GAT1 at the syntaxin 1A binding site. gamma-Aminobutyric Acid syntaxin 1A Rattus norvegicus
4 The syntaxin 1A-mediated reduction in GABA flux and efflux was mimicked by mutations in GAT1 at the syntaxin 1A binding site. gamma-Aminobutyric Acid syntaxin 1A Rattus norvegicus